Posts Tagged ‘hydroxychloroquine’

Trump Haters Hate Hydroxychloroquine Too

June 4, 2020

Hate is the gift which keeps on giving to haters, and the worst it gets, the more they thrive.

It’s telling that hydroxychloroquine (HCQ) has become a political issue. Hatred has grown so much that one is considered a stupid pro-Trump racist, if one falls for HCQ. Everyday, the New York Times comes out with a new anti-Trump article accusing him of promoting hydroxychloroquine (he has “promoted” all plausible and potential COVID treatments)…. But the anti-Trump plutocrats have a good reason to hate the cheap HCQ. And it has nothing they want to crow about.

There are many other anti-Trump articles, from all sorts of angles, but the  anti-Trump-anti-HCQ article of the day is a tradition, at the New York Times. Like Goebbels they keep repeating the same lie: there is no evidence that HCQ, etc… Aldous Huxley — ‘Sixty-two thousand four hundred repetitions make one truth.

Most of the plutocratically owned press (sorry about the pleonasm) the one which hates Trump, has made that drug, HCQ, a political issue by observing that it was “promoted by President Trump and others”… Then they add that there is no evidence that it can prevent or treat Covid-19. It reminds one of priests singing the same song everyday. 

Actually there is plenty of evidence that HCQ works, the only question is how well… for no less than three classes of reasons:

a) Hydroxychloroquine is an immune moderator, that’s how it works against Lupus. The worst problem with COVID is a crazed immune system, overreacting.

b) for other reasons, HCQ hinders the virus. The effects are modest, but strong enough to be used in comparison to developing therapeutics in the world’s largest study in vitro… Stanford, part of this study published that some drugs “worked twenty times better than HCQ”. A difference between these potential drugs and HCQ, is that HCQ has been used by more than two billion people (I, and Raoult, both from Senegal, used it for years. The NYT no doubt will tell me that’s why I insist to be fair and balanced about Trump… For relaxation, they will censor ten of my pro-HCQ comments…)

c) HCQ has been demonstrated to reduce viral loads. d) In countries (Russia, India, Turkey) where HCQ is used massively, the death rates are spectacularly lower.

In Turkey Hydroxychloroquine plus AZT, the Raoult treatment, is used massively at the first symptoms. The results are spectacular. Turkey has 170,000 cases of coronavirus, for a population of 82 millions. By comparison, Great Britain has had more than 40,000 DEAD (actually final government counting turns out 40% higher after a few weeks… So expect 50K soon). The Indian research body, ICMR uses it for the healthcare workers (HCWs) who are at an elevated risk of contracting Covid-19.

The ICMR study indicates that “simply initiating HCQ prophylaxis did not reduce the odds of acquiring Covid-19 infection among HCWs. However, with the intake of four or more maintenance doses of HCQ, the protective effect started emerging. A significant reduction of about 80 per cent in the odds of Covid-19 infection in the HCWs was identified with the intake of six or more doses of HCQ prophylaxis. This dose-response relationship added strength to the study outcomes.

It goes without saying that, if HCQ plus a macrolide (antiviral) antibiotic mitigates COVID, the biotech stocks are worth much less, and they trade indeed according to fake studies on HCQ.

Many of the great priests of the Demo-Plutocratic Party are wheelers and dealers. They want those biotech stocks to go ever higher. So down with the twenty dollar treatment removing most of the problem! And Trump fixing it! They want Trump to lose so that all jobs can be sent to China again!

In the last few weeks one doctor made a BILLION dollars from investing in Biotech (yes, 10^9 dollars). I don’t doubt the august doctor hates Trump, who is all what’s between him and another billion. After he turned out that The Lancet and NEJM authors were at best greedy monkeys (the self-dealing of the study was obvious) and their anti-HCQ “study” collapsed, biotech stocks collapsed in turn 15%! (I’m tracking very closely, don’t ask…)

So the Lancet just published a “study” which was grotesquely self-dealing… But the French government full of corrupt manslaughtering idiots, immediately forbid HCQ. France has become a very fascist country recently, with even going on beaches, parks and mountains outlawed, even if they were out of your door. Everyday is about the mood and caprices of the ex-banker of M&A, the young king, Macron I.

Meanwhile, Germany, next door, by reacting intelligently and locally rather than by being led by a corrupt young fascist banker-Fuhrer, had a death rate 20% of that of France. See, the Germans have become five times more intelligent than the French, as measured by COVID! It took a while, but there is hope! The German situation is a consequence of being led by a physicist, and local democracy (regional governments took the best decisions).

Meanwhile, the New York Times will keep on wishing with all its might that as many US citizens as possible die from COVID, as long as Trump goes down too… That’s because they want the return of their gilded age, with all jobs in the Chinese dictatorship… That’s why they support the New Jim Crow laws author that much (those laws date from 1994, when Senator Biden led the charge… Black Lives Matter is officially against them, so I don’t see how they could support their author).

People go around and ponder human nature. How come? Lincoln! Definition of goodness! Killed only a million Americans! OK, not his fault! Better Angels, come around! Let’s celebrate the intrinsic goodness of man, and of its butchers in particular, as long as they are our butchers! And what of the worst angels? When do they come around? What if hatred was an exponential phenomenon? Last night a 22 year old white youth was killed in Vallejo, California. He was unarmed, kneeling, hands up, a youth advocate from San Francisco. When the looting is alleged, the shooting starts (that statement is viewed as racist by the haters, by the way, that’s why I use it). The police officer shot five times, through his windshield: death can’t wait. Black lives matter! Do white lives matter too? Or do people have to be painted particular to be worth of racial considerations?

Hate is the gift which keeps on giving, and the worst it gets, the happier the haters.

Patrice Ayme

P/S: There has been a whole slew of anti-HCQ papers. Those I read were grossly incompetent, violating blatantly the “scientific method”. For example by comparing HCQ patients with non-HCQ patients… For just two days. After these two days, the non-HCQ were switched to HCQ, and the conclusion was that HCQ had no advantage… The data of two enormous studies published in the New England Journal of Medicine and The Lancet, came from a private company called Surgisphere, which claims to have granular patient-level information shared by 1,200 hospitals and health facilities on six continents (list not available). The founder and chief executive of Surgisphere, Dr. Sapan Desai, was listed as an author on both papers… Oops.

Didier Raoult’s CURE (Corona Chronicles II)

March 21, 2020

Infectious disease top world expert, professor Didier Raoult, discoverer of dozens of bacteria, an MD and PhD, leads a very large lab and institute he created in Marseilles [1]. Raoult’s findings are found in thousands of publications. Among many other things, he identified the causative agents of several diseases and discovered giant viruses… plausibly a new form of life, no less. (No doubt, if Raoult was American, or, a fortiori Swedish, he would already be a laureate of the Nobel Prize!)

When French citizens were evacuated from China by military flights, they were put under Raoult’s supervision. 

Very interesting results from France with a treatment combining hydroxychloroquine and a common antibiotic (which has an antiviral, yes, antiviral effect). That compound (and chloroquine itself) have been long known to have effects against some coronaviruses. (Trump himself promoted Raoult’s findings… enabling anti-Trump media to accuse Trump to be “non-scientific”!)

These are the first trial data. Yes this was a small trial, and it was open-label (as people are dying conducting double blind experiments is deeply unethical). However, the results are so striking, these objections can be overridden (larger scale studies have been launched in France).

Coronavirus Marseilles Raoult Work’s show that azithromycin plus hydroxychloroquine cures patients in 5 days. That probably works better, the earlier it’s applied.

26 patients were enrolled in the treatment group, with 16 controls. Six patients dropped out of the treatment group: 3 went to the ICU, one dropped out due to nausea, one left the hospital (apparently recovered?) and one died. No one left the two control groups. 15 male and 21 female patients were treated. 6 of them were asymptomatic, 22 had upper respiratory symptoms, and 8 had lower respiratory tract symptoms (all of those had confirmed COVID19 pneumonia by imaging).

The treatment group got 200mg of hydroxychloroquine sulfate three times a day. Six of those patients were also given 500mg azithromycin in addition. The antibiotic dealt with possible bacterial superinfection. Professor Raoult also uses azithromycin for its antiviral effects

There appears to be an effect of hydroxychloroquine. The effect of the hydroxychloroquine – azithromycin combination is notably stronger effect: down to zero virus as measured by nasal swab, in five (5) days.

These are two inexpensive generic drugs with a long history of use in humans. Chloroquine and hydroxychloroquine both can have notable side effects, for example, cardiopathy. However, that happens only under chronic usage for cramps (that was discontinued in the USA in the 2000s, for this particular pathology). Brought up in Black Africa, I got malaria more than once, and was given longer treatments of chloroquine. The  treatment of Raoult is only a few days, and should have no adverse effects. Also, as in the case of malaria, chloroquine can be used prophylactically. 

It better work; absent a treatment, COVID19 will be a disaster equal to the “Spanish Flu” of 1918, said, correctly, the Senator head of the Intelligence Committee who admitted to have engaged on insider trading after he was privately briefed. Biden claimed that “Medicare For All, doesn’t work” in Italy. He and his well-heeded PAC and media supporters insisted M4A was the cause of the massacre there. 

However, the USA has, relative to its population, fewer ICU and critical respiratory beds than Italy. Simply, because it blocked (non-US) people coming from China on January 31, the US is delayed by ten days the contagion relative to Italy 9the EU incompetently didn’t block this travel). Expect thousands of Americans to die. And don’t expect the disease to threaten less when it’s warmer: SARS-CoV-2 is progressing in tropical areas… Just as SARS-CoV did.  

Patrice Ayme

***

***

Didier Raoult (born March 13, 1952) is a French biologist. He holds MD and Ph.D. degrees and specializes in infectious diseases. In 1984, Didier Raoult created the Rickettsia Unit at Aix-Marseille University (AMU). He also teaches infectious diseases in the Faculty of Medicine of Aix-Marseille University, and since 1982 has supervised many M.D. and Ph.D. degrees.[1]

Raoult is a world reference for Q fever and Whipple’s disease.[11] 

Since 2008, Raoult has been the director of “URMITE” i.e. the Research Unit in Infectious and Tropical Emergent Diseases, collaborating with CNRS (National Center for the Scientific Research), IRD (Research for the Development Institute), INSERM (National Institute of Health and Medical Research) and the Aix Marseille University, in Marseille. His laboratory employs more than 200 people, including 86 very active researchers who publish between 250 and 350 papers per year and have produced more than 50 patents.[2] Didier Raoult is also involved in the creation of 8 startups to date.

Giant Viruses:

Raoult’s team was the first to discover very large size viruses.

In 2003, Didier Raoult identified with Bernard La Scola a giant amoebic virus, mimivirus,[16] and in 2004 established its genome.[17]

In 2016, this team found in mimivirus a defense mechanism preventing the implantation of virophages in the virus plant (MIMIVIRE).[18] Finally, it has been shown that this virophage could be integrated into the cells in the form of a pro-virophage and that it could be associated with transposon-like structures called transpovirons.[19]

They also discovered Marseilleviruses[20] and Faustoviruses.[21]

The discovery of giant viruses seriously undermines the classification of viruses. Didier Raoult has several times reported that giant viruses are of a different nature than other viruses and that they constitute a 4th branch of microbes known as TRUC for “Things Resisting Uncompleted Classifications”

New bacteria:

Since the 1990s, Raoult and his team have identified and described approximately 96 new pathogenic bacteria[9] and showed their implication in human pathologies. Two bacteria have been named for him: Raoultella planticola and Rickettsia raoultii.

***

[2] ““With all due respect to Medicare for all, you have a single-payer system in Italy,” Biden said to Sanders. It doesn’t work there. It has nothing to do with Medicare for all.

***

[This is the Tenth essay of mine on COVID19. The epidemic is rich in philosophical themes, and first of all, our degenerated civilization, and the need to reevaluate all its values!]


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