Posts Tagged ‘Raoult’

Raoult’s Hydroxychloroquine-Azithromycin Cure For Covid: 80 Patient Study

March 31, 2020

Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: an observational study
Running title: Hydroxychloroquine-Azithromycin and COVID-19

Long story short:

The light beige line denotes the patients who are contagious (shedding virus). Basically, none of the 80 patients shed virus after ten days. The median virus shedding time is 20 days (Chinese studies). Quinine-Azithromycin works!

[Authors [1]]
Abstract:
We need an effective treatment to cure COVID-19 patients and to decrease the virus carriage duration. In 80 in-patients receiving a combination of hydroxychloroquine and azithromycin. We noted a clinical improvement in all but one 86 year-old patient who died, and one 74 year old patient still in intensive care unit. A rapid fall of nasopharyngeal viral load tested by qPCR was noted, with 83% negative at Day7, and 93% at Day8. Virus cultures from patient respiratory samples were negative in 97.5% patients at Day5. This allowed patients to rapidly be discharged from highly contagious wards with a mean length of stay of five days. We believe other teams should urgently evaluate this cost-effective therapeutic strategy, to both avoid the spread of the disease and treat patients as soon as possible before severe respiratory irreversible complications take hold.
Keywords: COVID-19; SARS-CoV-2; hydroxychloroquine; azithromycin; PCR; culture.
Introduction:
In late December 2019, an outbreak of an emerging disease (COVID-19) due to a novel coronavirus (named SARS-CoV-2 latter) began in Wuhan, China and quickly spread in a substantial number of countries (1;2). The epidemic was declared a pandemic by the WHO on 12 March 2020 (3). According to a Chinese study, 80% of patients present with mild symptoms and the overall fatality rate is about 2.3%, although this rises to 8.0% in patients between the ages of 70 to 79 years and to 14.8% in those aged 80 years and over (4).
However, it is highly likely that there are a significant number of asymptomatic carriers in the population, and thus it is probable that the mortality rate has been overestimated. To take the example of the outbreak onboard the Diamond Princess cruise-ship, the fatality rate was 1.4%
(5). France is now facing the onslaught of COVID-19 with more than 25,000 cases, as March 26th, 2020 (5). Thus, there is a critical and urgent need for an effective treatment in order to cure symptomatic patients but also to decrease the duration of virus carriage and thus limit transmission in the community. Among the candidate drugs to treat COVID-19, repositioning
old drugs for use as an antiviral treatment is an interesting strategy, because knowledge about these drugs’ safety profile, side effects, posology and drug interactions are already well known (6;7).
Three in vitro studies have demonstrated that chloroquine phosphate inhibits SARS-CoV-2 (8;9) and two have demonstrated that hydroxychloroquine sulfate inhibits SARS-CoV-2 (8-10). Other studies have pointed out that drug repurposing may identify approved drugs that could be useful for the treatment of this disease including, notably, chloroquine,
hydroxychloroquine and azithromycin, as well as anti-diabetics such as metformin, angiotensin receptor inhibitors such as sartans, or statins such as simvastatin (11). In addition, chloroquine has demonstrated its efficacy in Chinese COVID-19 patients in clinical trials by reducing fever, improving CT imaging, and delaying disease progression (12-14), leading Chinese experts to recommend chloroquine-based treatment (500 mg twice per day for ten days) as a first line-treatment for mild, moderate and severe cases of COVID-19 (15).
In a preliminary clinical trial on a small cohort of COVID-19 patients, we demonstrated that those treated with hydroxychloroquine (600 mg per day, N=20 patients) had a significant reduction in viral carriage at D6-post inclusion, with 70% of patients testing negative for the virus through nasopharyngeal PCR, compared to untreated controls (N=16) with only 12.5% patients testing negative using PCR at D6-post inclusion (16). In addition, of the twenty patients who were treated with hydroxychloroquine, six received azithromycin for five days (for the purposes of preventing bacterial super-infection) and all (100%) were virologically cured at D6-post inclusion, compared to 57.1% of the remaining 14 patients (16). By contrast,
a Chinese study conducted in 30 COVID-19 patients showed no significant differences between patients treated with 400 mg per day during five days (N=15) and controls (N=15)
regarding pharyngeal carriage of viral RNA at day7, however, patients received multiple
additional treatments including antivirals (17).
A recent Chinese survey revealed that the median duration of viral shedding was 20.0 days (IQR 17.0–24.0) in survivors, but SARS-CoV-2 was detectable until death in non-survivors.
The shortest observed duration of viral shedding among survivors was eight days, whereas the longest was 37 days (18). Therefore, a treatment enabling the viral carriage to be cleared and COVID-patients to be clinically cured at an early stage would help limit the transmission of the virus.
In this report we describe our results in patients treated with hydroxychloroquine in combination with azithromycin over a period of at least three days, with three main endpoints:
i) clinical outcome ii) contagiousness as assessed by PCR and culture and iii) long of stay in infectious disease (ID) unit.
Methods:
The study was conducted at the University Hospital Institute Méditerranée Infection in
Marseille, France. Patients with PCR-documented SARS-CoV-2 RNA from a nasopharyngeal sample were admitted to our infectious diseases (ID) ward. It should be noted that six patients enrolled at our institute who were described in our first paper, with a six-day follow-up (N=6) (16), were also included in the present study, with a longer follow-up.
Clinical classification and clinical follow-up: 
Upon admission, patients were grouped into two categories: i) those with an upper respiratory tract infection (URTI) presenting with rhinitis and/or pharyngitis, and/or isolated low-grade fever and myalgia, and ii) those with lower respiratory tract infections (LRTI) presenting with symptoms of pneumonia or bronchitis. The time between the onset of symptoms and admission, and the time between the onset of symptoms and treatment was documented. Risk factors for severe COVID-19, including older age, cancer, cardiovascular disease, hypertension, and diabetes (4), as well as chronic obstructive pulmonary disease, obesity and
any immunosuppressive treatments were documented.

PA

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Authors: Philippe Gautret1,2,£, Jean-Christophe Lagier1,3,$, Philippe Parola1,2, Van Thuan Hoang1,2,4, Line Meddeb1, Jacques Sevestre1, Morgane Mailhe1, Barbara Doudier1, Camille Aubry1, Sophie Amrane1, Piseth Seng1, Marie Hocquart1, Julie Finance5, Vera Esteves Vieira1, Hervé Tissot Dupont1,3, Stéphane Honoré6,7, Andreas Stein1,3, Matthieu Million1,3, Philippe
Colson1,3, Bernard La Scola1,3, Véronique Veit8, Alexis Jacquier9, Jean-Claude Deharo10, Michel Drancourt1,3, Pierre Edouard Fournier1,2, Jean-Marc Rolain1,3, Philippe Brouqui1,3 Didier Raoult1,3* IHU-Méditerranée Infection, Marseille, France.
2Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France. 3Aix Marseille Univ, IRD, APHM, MEPHI, Marseille, France. 4Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam 5Assistance Publique de Marseille, Hôpital Nord, Explorations Fonctionnelles Respiratoires, Aix Marseille Université. 6 Service de Pharmacie, Hôpital Timone, AP-HM, Marseille, France. 7 Laboratoire de Pharmacie Clinique, Aix Marseille Université, Marseille, France 8 Assistance Publique de Marseille, Médecine Interne, Unité de Médecine Aigue Polyvalente (UMAP).
9 Department of Radiology and Cardiovascular Imaging, Aix-Marseille Université, UMR 7339, CNRS, CRMBM-CEMEREM (Centre de Résonance Magnétique Biologique et Médicale-Centre d’Exploration Métaboliques par Résonance Magnétique)
10 Assistance Publique de Marseille, Hôpital Timone, Cardiologie, Rythomologie, Aix-Marseille Université.
*Corresponding author: Didier Raoult. Didier.raoult@gmail.com

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P/S: The Raoult paper lists contraindications. Mostly people known to have problems with quinine and AZT…

QUORA Wants To Ban Me: I Said The $6.2 T Bipartisan Bill Is Mercantilism

March 30, 2020

Mercantilist economic policies aimed to build up the state, commerce and industry, and Mercantilist theorists charged the state with looking for ways to strengthen the economy… [1]

The Internet is manipulated by the censors which its extremely wealthy owners pay. Many of these geeks have low levels of education, and see offense where there is none. Before getting on Quora today I got a warning that one of my comments violated their policy, and I had to sign an electronic document telling me I was going to be banned, should I do it again. [2]

My comment was entirely technical… and in economy. There were no attack against any member of Quora. There were no insults against people dead or alive. I just sung the praises of “Mercantilism”, an economic theory under which most powers operated for many centuries. I referred to an essay explaining the distinction between “Mercantilism” and “Colbertism”. I cannot imagine why the comment was banned. Actually the 6.2 trillion dollar package just passed is an example of Colbertism… Everybody agrees to save Boeing, that’s Colbertism. I cannot possibly imagine why such a comment would be banned. But it was. We are dealing here with people who micromanage thinking and scholarship. First comic relief:

The Anti-Trumpers are completely insane, but, you know what? It works! As Hitler said, the bigger the lie, the more plausible it sounds. NYT had an article claiming:”Trump to New York: Drop Dead!” The hatred this sort of insanity brings actually makes the anti-Trumpers even more full of righteousness and hatred…

I was answering Peter Malmutt who wrote:

This stimulus was absolutely necessary because as you highlight, no economy no money. While this is structured very differently to the TARP (lessons learned, esp not to trust desperate bankers) and equity positions in some corporates could be an outcome, doesn’t this look like quasi-socialism? Isn’t that something that is taboo for the Republican Party ideology, although they also used to hold strong views on balanced budgets and maximum national debt levels?

In a first comment, I said that, indeed, it was socialism. Then I wrote the following comment, deleted by Quora:
“People who voted Republican in the past wanted to stay wealthy. In a static world, it meant balanced budgets and absolute limits on debt, to insure the value of money. However, the world is not static anymore. Europe is balancing budgets, and getting ever more poor, relatively speaking. The US and UK have been profligate: it works.

If the USA had balanced its budget in World War Two, the completely unbalanced Nazis would have won… The USA sent, for free, absolutely gigantic quantities of planes, tanks, trucks, to the USSR… Enough to turn the tide… Similarly the UK got immensely indebted to the USA to stay in the war. At the end of the war, the USSR had no industrial capacity (it was in the USA) and the UK had to surrender to the USA…

The COVID19 is an occasion for the hard sci fi edge of the US economy to get ahead… Firms like Gilead… Republicans have come to realize that one has to stay ahead, if one wants to thrive… Ahead of the virus, but not just the virus, as governor Cuomo said today… Trump is a billionaire entrepreneur who made his fortune inside the USA, and was long an enemy of the Reagan Revolution (he prefered subsidies… ;-))… And thus a left wing Democrat, relative to say, Biden or Clinton…
Trump literally captured the Republican Party and has been able to harness this new way of creating wealth… Just like the old one, ruling all over Europe and the USA, it’s called MERCANTILISM, but one should call it in its most striking version, COLBERTISM…
Colbert Good, Keynes Not So Smart (https://patriceayme.wordpress.com/2010/09/04/colbert-good-keynes-not-so-

Why was the comment deleted?

Probably because some plutocrat saw it, and perceived that it could be viewed as complementary to Trump (in spite of the crack about subsidies… and it’s true Trump harnessed New York construction subsidies, that’s why the NY gov set up subsidies…). Then the plutocrat, or servant thereof signaled to Quora one better terrorize that author, whose entire “answer” could be interpreted as all too favorable to Trump… Never mind that I approved of a BIPARTISAN BILL…

***

Trump Derangement Syndrome extends even to COVID. Here is what I read among the anti-Trump enraged and deranged:

“President Trump has turned to a French virologist with a history of criticizing climate science to offer the world hope amid the novel coronavirus pandemic.” Actually Raoult criticised poor meteorological predictions… which have gone indeed pretty bad recently, because the climate is changing too fast. But the TDS crowd has no limit:

Last week, Trump tweeted that the combination of two medicines could dramatically alter the often deadly course of COVID-19.

“HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine,” Trump wrote. He then cited a study published in the International Journal of Antimicrobial Agents that afforded little time for peer review.

Notice the viciousness: the paper was actually PEER REVIEWED in the most prestigious Journal. And published by said Journal. But now hacks who probably never studied calculus or biology are telling us that the peer review had “little time”. Yeah, guys, thousands of people are dying everyday.

PhD Raoult is the greatest star in his domain… And an MD, so he prescribed his drug, hydroxychloroquine, to more than 4,000 patients: it’s safer than quinine (which I got for years).

The World Wide Web is a treasure. But it’s full of parasites, vermin, viruses… How to distinguish truth from lies is difficult. Over the years I was banned from many Internet outlets, for “fantastic thinking” (the guy who accused me of this was the Harvey Weinstein of philosophy, a serial rapist), or from the European Tribune for having suggested that bankers bankrolled Hitler (they made an Internet search, they said, to prove only me in the entire world had this theory… It’s how the wealth of the Bush family was launched…), or the Daily Kos, for saying Obamacare would make the profit of the healthcare insurance industry greater (it did), or from the Guardian, for being a Jihadist… The fatwa against me from Pakistan Justice (!) Ministry for offending the famous Rophet, a proof, no doubt… Etc.

There should be a law of public utility forbidding censorship… Ah, but as a New York Times subscriber, for decades, I was censored more than 1,000 times… Sanders wanted such a law… But Sanders didn’t want to hurt Biden’s feelings… Thus demonstrating a congenital inability to become US president…

WW Web is Direct Democracy. The political system we have is Democracy through Representatives… Basically, as in China. Direct Democracy has to develop Debate Expertise. This is not a new debate: Socrates was obsessed by the notion of Direct Democracy versus Expertise. What I call “Democratic Institutions” were developed, in the Middle Ages, to answer Socrates. However they turned out to have seen their would-be Expertise been devoured by Will To Power. So now we have anonymous censors without any education telling us “Mercantilism” is an insult.

In any case, Marx, Engels, Proudhon (their inspiration) fustigated the owners of the workers. Now one should fustigate the owners, or more exactly enslavers of thoughts.

Patrice Ayme

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[1] The Wikipedia entry on Mercantilism I linked to is extremely bad, and denotes an anti-Mercantilist bias. That’s because Mercantilism is nationalistic, whereas the plutocratic globalization was leveraging internationalism to avoid taxation and legislation… Servants of plutocrats probably wrote the article… I will not bother modifying it: total loss of time, I would get in a fight with arrogant poisonous mice…

***

[2] Quora is an Internet outfit with intellectual pretense. It covers the full spectrum from unfathomably stupid, to extremely interesting… Depending upon who wrote the article, and what it is about.


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SoundEagle 🦅ೋღஜஇ

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Artificial Turf At French Bilingual School Berkeley

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in truth, only atoms and the void

West Hunter

Omnes vulnerant, ultima necat

GrrrGraphics on WordPress

www.grrrgraphics.com

Skulls in the Stars

The intersection of physics, optics, history and pulp fiction

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because all (Western) philosophy consists of a series of footnotes to Plato

Patrice Ayme's Thoughts

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